Treatments of Chlamydia Trachomatis and Neisseria Gonorrhoeae

نویسندگان

  • Ken Kun Zhao
  • KEN KUN ZHAO
  • Guantao Chen
  • Zhongshan Li
  • Jiawei Liu
چکیده

Chlamydia Trachomatis and Neisseria Gonorrhoeae rank as the two most commonly reported sexually transmitted diseases (STDs) in the United States. Under limited budget, publicly funded clinics are not able to screen and treat the two diseases for all patients. They have to make a decision as to which group of population shall go through the procedure for screening and treating the two diseases. Therefore, we propose a cubic integer programming model on maximizing the number of cured diseases. At the same time, a two-step algorithm is established to solve the cubic integer program. We further develop a web-server, which immediately make recommendation on identifying population groups, screening assays and treatment regimens. Running on the empirical data provided by the Centers for Disease Control and Prevention, our program gives more accurate optimal results comparing to MS Excel solver within a very short time. INDEX WORDS: Sexually Transmitted Disease, Optimization, Cubic Integer Programming, Knapsack Problem, Screening TREATMENTS OF CHLAMYDIA TRACHOMATIS AND NEISSERIA GONORRHOEAE

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تاریخ انتشار 2015